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"We're not saying that there's not a difference," says lead researcher Bruce G.

Bender, Ph D, of National Jewish Medical and Research Center in Denver.

In the United States and Canada, it is the first-generation antihistamine diphenhydramine. The product is not recommended for use to make a child sleep. It is marketed without a prescription by Johnson & Johnson subsidiary Mc Neil Consumer Healthcare.

Before 2007, Benadryl was marketed by Pfizer Consumer Healthcare.

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" April 25, 2003 -- Timely research for the start of hay fever season: Despite their higher cost, the newer, so-called "second generation" of more expensive "nonsedating" prescription antihistamines may be no more effective at preventing fatigue and memory lapses than older over-the-counter formulas such as Benadryl.

It is available as round, light salmon coloured tablets containing 10 mg of rupatadine (as fumarate) to be administered orally, once a day.Toxic Mechanism: They are less sedating due to the fact they are less lipophilic and do not cross the blood-brain-barrier as easily.They selectively inhibit the peripheral H1 receptors and therefore have a lower affinity for the central H1, muscarinic, alpha adrenergic and serotingeric (5-HT) receptors that the sedating anti-histamines do. Antihistaminic, anti-inflammatory, and antiallergic properties of the non-sedating second-generation antihistamine desloratadine: a review of the evidence. This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information.

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